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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 213-221 doi: 10.1007/s11705-015-1541-3

Abstract: previously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of targetnucleic acids.

Keywords： quione methide     DNA alkylation     reversible covalent reaction     bioconjugation     target-directed modificationof nucleic acids    

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Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 203-212 doi: 10.1007/s11705-016-1572-4

Abstract: Modeling structural and thermodynamic properties of nucleic acids has long been a challenge in the developmenthave been proved to be reliable to model small molecules, polypeptides and proteins, but their use on nucleicacids is still rather limited.In this article, the interactions between nucleic acids and a small molecule or ion were modeled by AMOEBAbio09

Keywords： nucleic acid     polarizable force field     AMOEBA    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliverydegradation, 2) avoidance of non-specific interactions with non-targeted tissues, 3) efficient entry into the targetengineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 519-525 doi: 10.1007/s11783-011-0326-2

Abstract: Application of directed evolution technology may be one of the most effective ways for improving thehydrolysis mechanism by cellulase, advances in cellulases (endoglucanase and -glucosidase) improvement by directedcharacteristics (for instance, thermal stability, pH adaptability and enzyme activity), limitations of directedevolution for cellulases, and the outlook for directed evolution for cellulase.

Keywords： biohydrogen     bioethanol     cellulase     cellulose     directed evolution    

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Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 608-623 doi: 10.1007/s11684-018-0644-x

Abstract: Diabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, “metabolic memory,” a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing glycemic control in diabetes due to their ability to regulate energy metabolism by binding and activating nuclear transcription factors such as farnesoid X receptor (FXR) in liver and intestine as well as the G-protein coupled receptor, TGR5, in enteroendocrine cells and pancreatic -cells. The downstream targets of BA activated FXR, FGF15/21, are also important for glucose/insulin homeostasis. In this review we will discuss the effect of BAs on glucose and lipid metabolism and explore recent research on establishing glycemic control in diabetes through the manipulation of BAs and their receptors in the liver, intestine and pancreas, alteration of the enterohepatic circulation, bariatric surgery and alignment of circadian rhythms.

Keywords： bile acids     metabolic memory     diabetes     circadian rhythm     bariatric surgery    

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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: There are many challenges in developing efficient and target specific delivery systems of small moleculeand nucleic acid drugs.

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 311-320 doi: 10.1631/FITEE.1400425

Abstract: latter normalizes at the level of nodes. (2) Treating undirected networks as equivalent to symmetric directednetworks, we expand the definition of gefura measures to the directed case. (3) It is shown how Brandes

Keywords： Networks subdivided in groups     Partitions     Gefura measures     Q-measures     Brokerage role     Directed and    

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Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 10,   Pages 838-847 doi: 10.1631/FITEE.1500069

Abstract: Each agent is assumed to be governed by a second-order consensus control law corresponding to a directedThe first is concerned with directed trees, which represent the class of topology with minimum informationThe second is concerned with a more general graph that can be reduced to a directed tree by contracting

Keywords： Multi-agent systems     Controllability     Directed tree    

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Catalytic conversion of biomass-derived compounds to various amino acids: status and perspectives

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 817-829 doi: 10.1007/s11705-022-2254-z

Abstract: Amino acids are important nitrogen-containing chemicals that have a variety of applications.Currently, fermentation is the widely employed method to produce amino acids; however, the products aremostly limited to natural amino acids in the L-configuration.Catalytic synthesis is an alternative approach for the synthesis of amino acids with different typesand α-hydroxyl acids, have been transformed into amino acids via the amination reaction in the

Keywords： biomass     amino acids     chitin     nitrogen-containing compounds     lignocellulose    

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Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 699-708 doi: 10.1007/s11705-021-2093-3

Abstract: In this work, an ionic strength directed self-assembly procedure is described for the preparation of

Keywords： layer-by-layer self-assembly     single bilayer     nanofiltration membrane     desalination    

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Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1458-7

Abstract:

•Tryptophan protein, and aromatic protein I/II were the key identified proteins.

Keywords： Sludge pretreatments     Dissolved organic nitrogen     Proteins     Amino acids     Structural equation model     Metagenomic    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleicacids and protein-nucleic acid complexes.Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids(SeNA) for nucleic acid crystallography.

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Characterization of soil low-molecular-weight organic acids in the Karst rocky desertification region

Xiaoliang LI, Xiaomin CHEN, Xia LIU, Lianchuan ZHOU, Xinqiang YANG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11783-012-0391-1

Abstract: Soil low-molecular-weight (LMW) organic acids play important roles in the soil-forming process and theIn this study, we quantified the contents of LMW organic acids (including lactate, acetate, formate,The concentration of total LMW organic acids in topsoil solution ranged from 0.358 to 1.823 μmol·g ,The concentrations of the LMW organic acids were significantly positive correlated each other.Significant positive correlations were also observed among individual LMW organic acids in soil solution

Keywords： Karst rocky desertification     low-molecular-weight (LMW) organic acids     distribution characteristics     soil    

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Optimization of pretreatment of Jatropha oil with high free fatty acids for biodiesel production

Supriyono SUWITO, Giuliano DRAGONE, Hary SULISTYO, Bardi MURACHMAN, Suryo PURWONO, José TEIXEIRA

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 210-215 doi: 10.1007/s11705-012-1282-5

Abstract: A central composite rotatable design and response surface methodology were used in order to investigate the individual and combined effects of the ethanol-to-oil ratio, H SO concentration, temperature and time of reaction on the reduction of free fatty acid (FFA) in jatropha oil. A quadratic polynomial model relating the reaction variables with FFA reduction was developed, presenting a good coefficient of determination ( = 0.893). For reducing FFA to less than 1%, the optimal combination was found to be 0.62 v·v ethanol-to-oil ratio (14.9 v·v ethanol-to-FFA ratio), 1.7% v·v H SO concentration, and 79 min reaction time at a reaction temperature of 54°C. These results are of great relevance to maximize methyl esters formation by transesterification using an alkaline catalyst.

Keywords： biodiesel     biofuel     esterification     free fatty acids     jatropha curcas oil    

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Mild and highly regioselective synthesis of biaryl acids via Rh(I)-catalyzed cross-dehydrogenative couplingof benzoic acids using sodium chlorite as oxidant

Yun Liu, Youquan Zhu, Chaojun Li

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 1,   Pages 3-8 doi: 10.1007/s11705-017-1693-4

Abstract: A mild and efficient synthesis for the biaryl acids via rhodium-catalyzed cross-dehydrogenative coupling

Keywords： biaryl acids     cross-dehydrogenative coupling     rhodium-catalyzed    

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Title Author Date Type Operation

DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Journal Article

Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Journal Article

Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Journal Article

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Journal Article

Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Journal Article

Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Journal Article

Catalytic conversion of biomass-derived compounds to various amino acids: status and perspectives

Journal Article

Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Journal Article

Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Characterization of soil low-molecular-weight organic acids in the Karst rocky desertification region

Xiaoliang LI, Xiaomin CHEN, Xia LIU, Lianchuan ZHOU, Xinqiang YANG

Journal Article

Optimization of pretreatment of Jatropha oil with high free fatty acids for biodiesel production

Supriyono SUWITO, Giuliano DRAGONE, Hary SULISTYO, Bardi MURACHMAN, Suryo PURWONO, José TEIXEIRA

Journal Article

Mild and highly regioselective synthesis of biaryl acids via Rh(I)-catalyzed cross-dehydrogenative couplingof benzoic acids using sodium chlorite as oxidant

Yun Liu, Youquan Zhu, Chaojun Li

Journal Article